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    <title>synbiointel.com — Research</title>
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      <title><![CDATA[MUC16 CAR-T Cuts Bladder Tumor Growth via Catheter]]></title>
      <link>https://synbiointel.com/news/muc16-car-t-intravesical-bladder-cancer-preclinical</link>
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      <pubDate>Fri, 26 Jun 2026 16:03:30 GMT</pubDate>
      <description><![CDATA[MUC16-targeting CAR T cells delivered via catheter controlled bladder tumors in mice, opening a local delivery route for solid tumor CAR-T.]]></description>
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      <title><![CDATA[TRIM Platform Stacks 3+ Crop Traits via Twin Prime Editing]]></title>
      <link>https://synbiointel.com/news/trim-platform-twin-prime-editing-crop-traits</link>
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      <pubDate>Fri, 05 Jun 2026 19:13:36 GMT</pubDate>
      <description><![CDATA[New genome engineering platform combines prime editing with knockouts for efficient multi-trait crop development]]></description>
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      <title><![CDATA[D&D-seq Maps DNA-Protein Contacts at Single-Cell Resolution]]></title>
      <link>https://synbiointel.com/news/dd-seq-base-editing-single-cell-dna-protein-mapping</link>
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      <pubDate>Fri, 05 Jun 2026 01:09:55 GMT</pubDate>
      <description><![CDATA[New method uses base editor-nanobody fusions to record DNA-protein interactions in individual cells]]></description>
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      <title><![CDATA[PRINCE System Enables Reversible Gene Editing with Small Molecules]]></title>
      <link>https://synbiointel.com/news/prince-reversible-gene-editing-small-molecules</link>
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      <pubDate>Thu, 28 May 2026 09:03:00 GMT</pubDate>
      <description><![CDATA[New CRISPR system allows researchers to turn gene editing on and off with small molecules]]></description>
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      <title><![CDATA[RNA Motifs Boost Prime Editing Efficiency 4x in New Study]]></title>
      <link>https://synbiointel.com/news/rna-motifs-boost-prime-editing-efficiency-study</link>
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      <pubDate>Wed, 20 May 2026 11:49:31 GMT</pubDate>
      <description><![CDATA[Engineered RNA-stabilizing motifs quadruple prime editing success rates through directed evolution approach]]></description>
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      <title><![CDATA[MD Anderson CAR-T Therapy Enters Phase I for Solid Tumors]]></title>
      <link>https://synbiointel.com/news/md-anderson-car-t-therapy-phase-1-solid-tumors</link>
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      <pubDate>Thu, 14 May 2026 23:05:00 GMT</pubDate>
      <description><![CDATA[UT MD Anderson's novel CAR-T approach targets solid tumor challenges with enhanced persistence and trafficking capabilities.]]></description>
      <category>research</category>
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      <title><![CDATA[Pichia Pastoris Cell-Free System Cuts Protein Production Costs]]></title>
      <link>https://synbiointel.com/news/pichia-pastoris-cell-free-protein-production-costs</link>
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      <pubDate>Wed, 13 May 2026 16:00:44 GMT</pubDate>
      <description><![CDATA[New yeast-based cell-free expression system promises significant cost reductions for therapeutic protein manufacturing]]></description>
      <category>research</category>
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      <title><![CDATA[Benchling Model Hub Embeds Scientific AI Into Biotech Workflows]]></title>
      <link>https://synbiointel.com/news/benchling-model-hub-scientific-ai-workflows</link>
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      <pubDate>Wed, 13 May 2026 13:38:22 GMT</pubDate>
      <description><![CDATA[Benchling launches Model Hub to integrate scientific AI models directly into R&D workflows]]></description>
      <category>research</category>
    </item>
    <item>
      <title><![CDATA[DNA Guides Reprogram Cas12a for Direct RNA Targeting]]></title>
      <link>https://synbiointel.com/news/dna-guides-cas12a-rna-targeting</link>
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      <pubDate>Fri, 08 May 2026 10:18:50 GMT</pubDate>
      <description><![CDATA[Synthetic DNA guides enable Cas12a nucleases to directly target RNA, expanding CRISPR applications beyond genome editing]]></description>
      <category>research</category>
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      <title><![CDATA[DNA Supercoiling Rules Could Transform Synthetic Gene Circuits]]></title>
      <link>https://synbiointel.com/news/dna-supercoiling-gene-syntax-synthetic-circuits</link>
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      <pubDate>Mon, 04 May 2026 23:16:28 GMT</pubDate>
      <description><![CDATA[New research reveals how gene syntax controls DNA supercoiling to modulate neighboring gene expression by up to 10-fold]]></description>
      <category>research</category>
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      <title><![CDATA[New Tensor Method Optimizes RNA Design Under Codon Constraints]]></title>
      <link>https://synbiointel.com/news/tensor-rna-design-codon-optimization-breakthrough</link>
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      <pubDate>Tue, 21 Apr 2026 17:45:37 GMT</pubDate>
      <description><![CDATA[Researchers develop tensor-based models that solve RNA sequence design while respecting codon constraints]]></description>
      <category>research</category>
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      <title><![CDATA[Scientists Engineer DGR Systems for Targeted Hypermutagenesis in E.coli]]></title>
      <link>https://synbiointel.com/news/dgr-targeted-hypermutagenesis-ecoli-directed-evolution</link>
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      <pubDate>Thu, 16 Apr 2026 21:36:42 GMT</pubDate>
      <description><![CDATA[Nature Biotechnology study demonstrates programmable diversity-generating retroelements for precise directed evolution]]></description>
      <category>research</category>
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      <title><![CDATA[Small-Molecule Base Editor Cuts Cancer Gene Screen Time 75%]]></title>
      <link>https://synbiointel.com/news/inducible-base-editor-cancer-genomics-platform</link>
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      <pubDate>Wed, 15 Apr 2026 21:44:15 GMT</pubDate>
      <description><![CDATA[New platform enables precise in vivo cancer gene screens with 4-fold reduced toxicity and temporal control]]></description>
      <category>research</category>
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      <title><![CDATA[iPSC Manufacturing Cuts NK Cell Therapy COGS by 65% vs Autologous]]></title>
      <link>https://synbiointel.com/news/ipsc-manufacturing-cuts-nk-cell-therapy-cogs-65-percent</link>
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      <pubDate>Wed, 15 Apr 2026 16:00:32 GMT</pubDate>
      <description><![CDATA[Universal master cell banks slash production costs and patient attrition in NK cell therapies]]></description>
      <category>research</category>
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      <title><![CDATA[CRISPR Gene Editing Creates Powdery Mildew-Resistant Gerbera Daisies]]></title>
      <link>https://synbiointel.com/news/crispr-powdery-mildew-resistant-gerbera-daisies</link>
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      <pubDate>Sun, 29 Mar 2026 21:05:50 GMT</pubDate>
      <description><![CDATA[First CRISPR-edited ornamental flowers show complete resistance to powdery mildew fungal infection]]></description>
      <category>research</category>
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    <item>
      <title><![CDATA[Sorghum CRISPR Screen Maps 10K Promoter Variants]]></title>
      <link>https://synbiointel.com/news/sorghum-crispr-promoter-variants-gene-expression</link>
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      <pubDate>Fri, 27 Mar 2026 11:31:18 GMT</pubDate>
      <description><![CDATA[Nature study identifies CRISPR-accessible mutations in sorghum promoters that boost gene expression]]></description>
      <category>research</category>
    </item>
    <item>
      <title><![CDATA[CAR-M Cells Target Cancer Metabolites for Solid Tumor Treatment]]></title>
      <link>https://synbiointel.com/news/car-m-cells-target-cancer-metabolites-solid-tumors</link>
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      <pubDate>Tue, 24 Mar 2026 19:27:40 GMT</pubDate>
      <description><![CDATA[Engineering immune cells to detect cancer metabolites shows promise for treating hard-to-reach solid tumors]]></description>
      <category>research</category>
    </item>
    <item>
      <title><![CDATA[Singapore AI Tool Boosts Gene Editing Precision by 40%]]></title>
      <link>https://synbiointel.com/news/singapore-ai-gene-editing-precision-boost</link>
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      <pubDate>Wed, 18 Mar 2026 07:32:29 GMT</pubDate>
      <description><![CDATA[NUS researchers develop AI system that predicts optimal editing conditions, reducing off-target effects to below detection]]></description>
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